反应详情

温度

110 °C

A solution of 4.7 g. of 2-(α-naphthyl)ethyl bromide and 6.6 g. of ethyl p-aminobenzoate in 50 ml. of hexamethylphosphoramide is stirred and heated at 110° C. for 16 hours. The mixture is cooled, diluted with 50 ml. of water and filtered to give a crude product, which is recrystallized from ethanol. Recrystallization gives ethyl 4-[2-(α-naphthyl)ethylamino]benzoate as white crystals, m.p. 104°-106° C.

1. temperatureThe mixture is cooled
2. additiondiluted with 50 ml
3. filtrationof water and filtered
4. customto give a crude product, which
5. customis recrystallized from ethanol
6. customRecrystallization