Chloroacetyl chloride → HCID 12818625, compound

Participants

Reaction Steps

A stirred mixture of 4 g. of 1-allyl-4-amino-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester in 30 ml. of chloroacetyl chloride was heated under reflux for 1 hour. The chloroacetyl chloride was evaporated in a rotary evaporator and the residue was triturated with 20 ml. of ethyl acetate. The insoluble material was collected and was recrystallized from ethyl acetate to give 1.2 g. of product, m.p. 145°-148° C.

Provenance & Evidence