Triethylamine → HCID 13061696, compound

Participants

Reaction Steps

A mixture of 4-amino-2-(1-piperazinyl)-6,7,8-trimethoxyquinazoline hydrochloride (4.0 g) and triethylamine (4.1 g) in butanol (250 ml) was stirred for 15 min and 2-chlorobenzthiazole (1.7 g) was added. The resulting mixture was refluxed for 20 hr, concentrated to about 150 ml, cooled and filtered. The precipitate was washed with water, dried and crystallized from methanol to give the title compound (2.2 g): mp>250° C.; ir (nujol) 3370, 3300 and 3610 cm-1 ; uv max (MeOH) 225 (ε=45,900), 250 (ε=56,700), 277 (ε=45,200) and 353 nm (ε=5,100); nmr (DMSO-d6) δ3.7 (m, 8H), 3.8 (s, 6H), 3.95 (s, 3H) and 7.3 (m, 7H); and Anal. Calcd. for C22H24N6O3S: C, 58.40% H, 5.30% N, 18.58% and Found: C, 58.22% H, 5.50% N, 18.62%.

Provenance & Evidence