Hydrochloric Acid → HCID 57092259, compound

Participants

Reaction Steps

3.5 g of 3α,6α-dihydroxy-5β-cholest-24-ene and 10.2 g of ρ-toluenesulfonyl chloride were dissolved in 90 ml of dry pyridine and then kept in a refrigerator for 48 hours. The mixture was poured into 300 ml of ice-water and the pH adjusted to 3 by adding concentrated HCl. After stirring for 30 minutes, the precipitate was removed by filtration, washed 4 times with 100 ml portions of water and dissolved in 300 ml of chloroform. The chloroform solution was washed with 30 ml of 5% sodium bicarbonate solution, four times with 50 ml of water solution, and dried. The solvent was evaporated and the residue dried. The yield was 5.1 g of a white solid (83%) identified from ir and nmr data as 3α,6α-ditosyloxy-5β-cholest-24-ene.

Provenance & Evidence