Pyridine → HCID 13055588, compound

Participants

Reaction Steps

Under an atmosphere of nitrogen, 100 mg of chromium trioxide and 0.5 g of infusorial earth were added to 0.162 ml of pyridine in 3 ml of methylene chloride, and the mixture was stirred for 15 minutes at room temperature. 55 mg of the 3-hydroxy compound (prepared as described in Example 1) in 1 ml of methylene chloride were added thereto at 0° C., and the mixture was stirred for 20 minutes at the same temperature. To the reaction solution obtained was added 1 g of sodium bisulphate and, after stirring for 20 minutes at 0° C., the mixture was filtered through a magnesium sulphate layer. The filtrate was concentrated under reduced pressure. The residue obtained was purified by column chromatography on silica gel using a mixture of cyclohexane and ethyl acetate (6:1) as eluent to obtain 42 mg of the title compound having the following physical characteristics:

Provenance & Evidence