Acetic Acid → HCID 12832925, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 42 mg of the tetrahydropyran-2-yloxy compound (prepared as described in Example 2), 0.4 ml of 65% v/v aqueous acetic acid, and 4 drops of tetrahydrofuran was stirred for 5 minutes at 80° C. The reaction solution was diluted with ethyl acetate, washed successively with water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulphate, and concentrated under reduced pressure. The residue obtained was purified by column chromatography on silica gel using a mixture of cyclohexane and ethyl acetate (2:1) as eluent to obtain 12.6 mg of the title compound having the following physical characteristics:

Provenance & Evidence