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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1703293Generated: October 30, 2026

1-methyl-1H-pyrrole-3-carboxylic acid → Methyl 1-methyl-5-cyclohexylcarbonylpyrrole-3-carboxylate

https://huagongshe.com/reaction/1703293

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-methyl-1H-pyrrole-3-carboxylic acidHCID 10154054—
ReactantMethyl 1-methyl-5-(3-chlorobenzoyl)pyrrole-3-carboxylateHCID 12783822—
ProductMethyl 1-methyl-5-cyclohexylcarbonylpyrrole-3-carboxylateHCID 20401039—

Reaction Steps

Belgian patent 870,910 (published Mar. 29, 1979) discloses preparation of analogous 1-alkyl-5-acylpyrrole-3-carboxylates, specifically exemplifying preparation of methyl 1-methyl-5-(3-chlorobenzoyl)pyrrole-3-carboxylate by Friedel-Crafts acylation of 1-methylpyrrole-3-carboxylic acid followed by esterification and separation from the 4-acyl isomer.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04351843
Source datasetuspto-grants-1982_09
ORD IDord-e8d6f388796349dabc312d472ec10a85
Source noteuspto-grants-1982_09