反应详情

Methyl 1-methyl-5-benzoylpyrrole-2-carboxylate (0.78 g.) was heated on a steam bath for 1 hour with 40 ml. of 1 N sodium hydroxide and 20 ml. of methanol. The reaction mixture was cooled to room temperature, extracted with ether, made acid with conc. hydrochloric acid and 1-methyl-5-benzoylpyrrole-2-carboxylic acid recovered by filtration (0.47 g., m.p. 178°-181° C.). Recrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.).

1. extractionextracted with ether
2. filtrationrecovered by filtration (0.47 g., m.p. 178°-181° C.)
3. customRecrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.)