Sodium Hydroxide → HCID 54233054, compound

Participants

Reaction Steps

A solution of 1.74 g of 1 (10 mmoles), 1.91 g of p-(4-morpholinyl)benzaldehyde (10 mmoles), and two pellets of sodium hydroxide (about 0.4 g) in 40 ml of ethanol was stirred under nitrogen at room temperature for 70 hr. The reaction mixture was cooled in an ice bath and the precipitated yellow solid 3-[4-(4-morpholinyl)phenyl]-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-2-propen-1-one was collected by filtration and washed with cold ethanol. Yield: 2.9 g (83%); m.p. 138° to 140°. λmax (EtOH): 390 nm (ε=28,100), 270 nm (ε=13,700). Calcd for C23H25NO2 : c, 79.51; H, 7.25; N, 4.03. Found: C, 78.72, 79.02, 78.75; H, 7.22, 7.26, 7.23; N, 3.88, 3.87, 3.91.

Provenance & Evidence