1-(2-Furoyl)piperazine → HCID 20506420, compound

HRID 1703371Notes

Reaction equation

HRID 1703371 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[C:5]([O:16][CH3:17])[C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)=[O:24]>C(O)CC(C)C>[ClH:1].[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23]([N:25]1[CH2:26][CH2:27][N:28]([C:2]2[N:11]=[C:10]([NH2:12])[C:9]3[C:4](=[C:5]([O:16][CH3:17])[C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=3)[N:3]=2)[CH2:29][CH2:30]1)=[O:24]

Participants

4

Reactant 2

HCID 5502061-(2-Furoyl)piperazineHCID 12920006HCID 12920006, compound

Product 1

HCID 20506420HCID 20506420, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 2,6-dichloro-4-amino-7,8-dimethoxyquinazoline (1.50 g., 5.47 mmole) and 1-(2-furoyl)piperazine (1.08 g., 5.99 mmole) was refluxed in 40 ml. isoamyl alcohol for 2 hours and then cooled overnight. The resulting solid was filtered and recrystallized from methanol/ether to yield 1.83 g. (74%) of pure final product, M.P., 208°-9° C.

Workup

  1. temperaturewas refluxed in 40 ml
  2. temperaturecooled overnight
  3. filtrationThe resulting solid was filtered
  4. customrecrystallized from methanol/ether
  5. customto yield 1.83 g

Sources & evidence

ORD record
ord-6296f4888a5742aba45336d2279f079c
Source dataset
uspto-grants-1982_09
Patent number
US04351940

Reaction notes

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