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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1703372Generated: October 30, 2026

1-(2-Furoyl)piperazine → 2-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride

https://huagongshe.com/reaction/1703372

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Furoyl)piperazineHCID 550206—
Reactant2,6-Dichloro-7-methoxyquinazolin-4-amineHCID 12920007—
SolventIsoamyl AlcoholHCID 31260—
Product2-[4-(2-Furoyl)piperazine-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochlorideHCID 2050639979%

Reaction Steps

The title compound was prepared similarly by refluxing 2,6-dichloro-4-amino-7-methoxyquinazoline and 1-(2-furoyl)piperazine in isoamyl alcohol, M.P. 229°-31° C., 79% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04351940
Source datasetuspto-grants-1982_09
ORD IDord-d4c8bfcdf07847fb8a745973b0d442e3
Source noteuspto-grants-1982_09