Thiazolidine → HCID 20506426, compound

HRID 1703379Notes

Reaction equation

HRID 1703379 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[S:17]1[CH2:21][CH2:20][NH:19][CH2:18]1>ClC1C=CC=CC=1>[ClH:16].[S:17]1[CH2:21][CH2:20][N:19]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:18]1

Participants

4

Reactant 2

HCID 10444ThiazolidineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 1

HCID 20506426HCID 20506426, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of 4.8 g. (0.02 mole) of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 4.5 g. (0.05 mole) of thiazolidine in 50 ml. of chlorobenzene is heated at reflux for 18 hours, cooled to room temperature and the precipitate collected by filtration to give the title compound which was purified by recrystallization.

Workup

  1. additionA mixture of 4.8 g
  2. temperatureat reflux for 18 hours
  3. filtrationthe precipitate collected by filtration

Sources & evidence

ORD record
ord-402540824b4347f2919b3f9db717936a
Source dataset
uspto-grants-1982_09
Patent number
US04351940

Reaction notes

Loading…