4-Hydroxypyrrolidine → HCID 20506397, compound

HRID 1703380Notes

Reaction equation

HRID 1703380 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[NH:18]1[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]1>C(O)CC(C)C>[ClH:12].[OH:23][CH:20]1[CH2:21][CH2:22][N:18]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=3)[N:5]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 12920006HCID 12920006, compound

Product 1

HCID 20506397HCID 20506397, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 4-amino-2,6-dichloro-7,8-dimethoxyquinazoline (5.48 g., 0.020 mole) and 3-pyrrolidinol (2.18 g., 0.025 mole) in 150 ml. of isoamyl alcohol is heated at reflux for five hours then cooled in ice. The precipitated product is collected by filtration and purified by recrystallization to obtain the title compound.

Workup

  1. temperatureat reflux for five hours
  2. temperaturethen cooled in ice
  3. filtrationThe precipitated product is collected by filtration
  4. custompurified by recrystallization

Sources & evidence

ORD record
ord-b3ed801d88594bfdb7948281fa7e2502
Source dataset
uspto-grants-1982_09
Patent number
US04351940

Reaction notes

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