2-Chromanecarbonyl chloride → 2-[4-(2,3-Dihydro-4H-benzopyran-2-carbonyl)-piperazin-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride

HRID 1703384Notes

Reaction equation

HRID 1703384 reaction equation
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31](Cl)=[O:32]>CO>[ClH:18].[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:2][CH2:3]1)=[O:32]

Participants

4

Reactant 2

HCID 27945832-Chromanecarbonyl chlorideHCID 20506419HCID 20506419, compound

Product 1

HCID 205064342-[4-(2,3-Dihydro-4H-benzopyran-2-carbonyl)-piperazin-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 0.10 mole of 2-(piperazin-1-yl)-4-amino-6-chloro-7-methoxyquinazoline in 300 ml. of methanol is added with vigorous stirring, 0.10 mole of 2,3-dihydro-4H-benzopyran-2-carboxylic acid chloride. After the addition is complete, the mixture is stirred for three hours at room temperature and the precipitated title compound is collected by filtration.

Workup

  1. additionAfter the addition
  2. customthe precipitated title compound
  3. filtrationis collected by filtration

Sources & evidence

ORD record
ord-404a6cd35cc34518aeba468f79f451a6
Source dataset
uspto-grants-1982_09
Patent number
US04351940

Reaction notes

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