Morpholine → 2-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

HRID 1703386Notes

Reaction equation

HRID 1703386 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CC(CC)=O>[ClH:16].[N:17]1([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 1

HCID 205063952-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To 500 ml. of methylethylketone is added 0.1 mole of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 0.12 mole of morpholine and the mixture is refluxed overnight. After cooling in ice-water the solid precipitated is collected by filtration, washed with ether and air dried to obtain the title compound.

Workup

  1. temperaturethe mixture is refluxed overnight
  2. customprecipitated
  3. filtrationis collected by filtration
  4. washwashed with ether and air
  5. customdried

Sources & evidence

ORD record
ord-a396b27f962b49a89e7aa289ef0a254f
Source dataset
uspto-grants-1982_09
Patent number
US04351940

Reaction notes

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