HCID 22761198, compound → HCID 21330037, compound

HRID 1703431Notes

Reaction equation

HRID 1703431 reaction equation
[C:1]1([N:7]2[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:23])[C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>C(O)C>[C:1]1([N:7]2[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:23])[C:14]3[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 22761198HCID 22761198, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21330037HCID 21330037, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 10 g. of 1-phenyl-3-(4-nitrobenzamido)pyrrolidine in 250 ml. of 95% ethanol containing 5% palladium on charcoal was shaken in a Paar hydrogenator in three atmospheres of hydrogen at room temperature. The reduction mixture was filtered and the filtrate concentrated to give 3.8 g. of crystalline product which melted at 213-216° C.

Workup

  1. additionA suspension of 10 g
  2. filtrationThe reduction mixture was filtered
  3. concentrationthe filtrate concentrated
  4. customto give 3.8 g

Sources & evidence

ORD record
ord-acf2d78f40af45738bf479f9891415c8
Source dataset
uspto-grants-1978_11
Patent number
USRE029828

Reaction notes

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