反应详情

153 g (1.1 mol) of p-nitrophenol, 1.3 liters acetone and 336 g (1.0 mol) of ethyl-α-bromo-tetradecanoate were placed in a 5-liter 3-necked flask and heated on a steam bath with stirring, for 60 hours. The product was filtered to remove inorganic salt and then the acetone was distilled off under vacuo. The residual oil was taken up in hexane, filtered, and concentrated under vacuo. Yield of Intermediate I was 361 g. TLC Analysis (benzene) showed only one spot, indicating a single product.

1. temperatureheated on a steam bath
2. filtrationThe product was filtered
3. customto remove inorganic salt
4. distillationthe acetone was distilled off under vacuo
5. filtrationfiltered
6. concentrationconcentrated under vacuo