Phenyl isocyanate → HCID 22761475, compound

HRID 1703452Notes

Reaction equation

HRID 1703452 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:10]1([CH2:16][C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[C:18]=2[OH:25])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C1C=CC=CC=1>[N:10]1([CH2:16][C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[C:18]=2[O:25][C:8](=[O:9])[NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 2626172,4-dimethyl-6-(piperidin-1-ylmethyl)phenol

Product 1

HCID 22761475HCID 22761475, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

29.75 g (0.25 mol) of phenylisocyanate are introduced dropwise at 0° to 5° C. into a solution of 54.75g (0.25 mol) of 2-(piperidinomethyl)-4,6-dimethylphenol in 80 ml of anhydrous benzene. The reaction mixture is stirred at room temperature for 4 hours. The precipitated carbamic acid ester is suction filtered and washed with petroleum ether (b.p. 30°-50° C.).

Workup

  1. filtrationfiltered
  2. washwashed with petroleum ether (b.p. 30°-50° C.)

Sources & evidence

ORD record
ord-c2b884e5648e46f2954bd7de8be3a7e7
Source dataset
uspto-grants-1978_11
Patent number
US04124545

Reaction notes

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