3-Aminorifamycin S → 3-Amino-rifamycin

Participants

Reaction Steps

8 g 3-amino-rifamycin S were dissolved in 30 ml diglyme and the solution was then added with 2 g sodium ascorbate dissolved in 5 ml water. The solution of 3-amino-rifamycin SV thus obtained was heated to 50° C. and then added with 4.4 g 4-carboxybenzoic aldehyde. The solution was stirred at this temperature for 15 minutes and then after adding 30 ml chloroform was again stirred at 50° C. for 4 hours. The reaction mixture was then added with 300 ml chloroform, washed with an aqueous solution of sodium metabisulphite and then with water.

Provenance & Evidence