HCID 22761659, compound → HCID 22761656, compound

Participants

Reaction Steps

The solution of 350 mg of N-(2-methoxymethyl-4-nitrophenyl)-4-chlorophthalimide is hydrogenated over 200 mg of 5% rhodium on carbon at 2.5 atmospheres of hydrogen pressure for 4 hours. After filtration from the catalyst, the residue is refluxed for 24 hours in 5 ml of xylene. After evaporation of the solvent, the residue is dissolved in acetone and the solution neutralized with ethereal hydrogen chloride, to yield the N-(2-methoxymethyl-4-aminophenyl)-4-chlorophthalimide hydrochloride melting at 255°-257°.

Provenance & Evidence