HCID 22761655, compound → HCID 22761649, compound

Participants

Reaction Steps

The solution of 300 mg of N-(2-ethoxymethyl-4-nitrophenyl)-4-chlorophthalimide in 40 ml of ethyl acetate is hydrogenated with 200 mg of 5% rhodium on carbon at 2.5 atmospheres of hydrogen pressure for 3 hours. After filtration from the catalyst the residue is refluxed for 24 hours in 5 ml of xylene, the solution evaporated and the residue crystallized from diethyl ether, to give the N-(2-ethoxymethyl-4-aminophenyl)-4-chlorophthalimide melting at 154°-156°.

Provenance & Evidence