Methane → HCID 20377694, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-{3-(5-methoxycarbonyl-thieno[2,3-b]thien-2-yl)carbonyl-phenyl}hexanoate (29.6 g), suspended in a mixture of potassium hydroxide pellets (15.5 g), distilled water (50 cc) and ethanol (100 cc), is stirred for 17 hours at a temperature of about 20° C. The solvents are distilled off under reduced pressure (30 mm Hg) at 40°-50° C. and the residue is dissolved in distilled water (150 cc). The solution obtained is stirred with decolourizing charcoal (0.5 g), filtered and acidified to pH 1 by the addition of a 5N aqueous solution of hydrogen chloride. The resulting crystals are filtered off, washed three times with distilled water (total 150 cc) and dried under reduced pressure (20 mm Hg) at 70° C. in the presence of potassium hydroxide pellets. Crude 2-{3-(5-carboxy-thieno[2,3-b]thien-2-yl)carbonyl-phenyl}hexanoic acid (28.4 g), melting at 208° C., is thus obtained.

Provenance & Evidence