Iodine → HCID 70610342, compound

HRID 1703555Notes

Reaction equation

HRID 1703555 reaction equation
[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I:20]I>C1C=CC=CC=1>[I:20][C:8]1([CH2:16][C:17]([OH:19])=[O:18])[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:15]=[C:11]2[CH:12]=[CH:13][CH:14]=[C:10]2[O:9]1

Participants

4

Reactant 2

HCID 807IodineHCID 70609976HCID 70609976, compound

Product 1

HCID 70610342HCID 70610342, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2.08 g. (8.25 mmoles) of 3-phenyl-7-benzofuranacetic acid in 10 ml. of benzene at 60° C. is slowly added small portions of yellow mercuric oxide (1.45 g., 6.7 mmoles) and iodine (2.09 g., 8.25 mmoles). After about two hours the mixture is filtered, then the filtrate is evaporated to dryness to provide 2-iodo-3-phenyl-7-benzofuranacetic acid.

Workup

  1. customat 60° C.
  2. filtrationAfter about two hours the mixture is filtered
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-5176dae9d1d14599b1be723c2996772a
Source dataset
uspto-grants-1978_11
Patent number
US04124704

Reaction notes

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