Aluminium lithium hydride → HCID 86736136, compound

Participants

Reaction Steps

15 g of (3aRS, 4SR, 7aRS)-4-p-chlorophenyl-hexahydro-4-hydroxy-1-indoline carboxylic acid ethyl ester and 4 g of lithium aluminum hydride in 100 ml of tetrahydrofuran were heated at reflux for 15 hours. Any remaining lithium aluminum hydride was destroyed by the addition of water. Partition between water and diethyl ether afforded after separation and working up of the organic phase the title compound as an oil (M.P. of the face base from diethyl ether/petroleum ether 98°-101°).

Provenance & Evidence