HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 5-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate | HCID 271299 | — |
| Reactant | Orthoformic acid | HCID 5231666 | — |
| Product | 5-[(Ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester | HCID 86736141 | 87% |
Reaction Steps
84.6 g. of 1-methyl-4-carboethoxy-5-aminopyrazole and 74.1 g. of orthoformic acid triethyul ester are heated together until the splitting off of ethanol has ended. The oily residue is distilled under oil pump vacuum to obtain 5-[(ethoxy-methylene)amino]-1-methyl-1h-pyrazole-4-carboxylic acid, ethyl ester b.p. 98°-102°; m.p. 32°-34° (yield87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04124764 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-776f3c41047e4bc2bc33d490672d8636 |
| Source note | uspto-grants-1978_11 |