Nitric Acid → 5-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

HRID 1703649Notes

Reaction equation

HRID 1703649 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH2:10][OH:11].[N+]([O-])(O)=O>>[CH3:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][C:3]=1[CH:10]=[O:11]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 12493277HCID 12493277, compound

Product 1

HCID 124932825-Methyl-2-n-propyl-4-imidazolecarboxaldehyde

Procedure

An 80 gm. portion of 5-methyl-2-n-propyl-4-imidazolemethanol is oxidized with 67.3 ml. of concentrated HNO3. A second portion of 101.4 gm. of the above compound is oxidized with 77 ml. of the acid. The reaction mixtures are combined, neutralized and worked up as in Example 25, giving the desired product, m.p. 126°-129° C.

Workup

  1. customThe reaction mixtures

Sources & evidence

ORD record
ord-119bffd7f1ac4d869fe4c2608d56b312
Source dataset
uspto-grants-1978_11
Patent number
US04124766

Reaction notes

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