反应详情

A solution of 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (25.0 g., 43.8 mmol) and sodium methoxide (400 mg.) in methanol (200 ml.) was refluxed for 45 min. The solution was neutralized with Bio-Rad AG50-X2 (H), filtered and the filtrate was concentrated to a syrup. Crystallization of the syrup from methanolethyl acetate provided 8.0 g. (70.5%) of product with M.P. 117-199°.

1. filtrationfiltered
2. concentrationthe filtrate was concentrated to a syrup
3. customCrystallization of the syrup from methanolethyl acetate
4. customprovided 8.0 g