Sodium Methoxide → 38934-69-9

HRID 1703728Notes

Reaction equation

HRID 1703728 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C@@H:10]2[O:32][C@H:31]([CH2:33][O:34]C(=O)C3C=CC=CC=3)[C@@H:21]([O:22]C(=O)C3C=CC=CC=3)[C@H:11]2[O:12]C(=O)C2C=CC=CC=2)[N:6]=1)=[O:4].C[O-].[Na+]>CO>[CH3:1][O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C@@H:10]2[O:32][C@H:31]([CH2:33][OH:34])[C@@H:21]([OH:22])[C@H:11]2[OH:12])[N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 134568041-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester

Product 1

HCID 1559016138934-69-9

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (25.0 g., 43.8 mmol) and sodium methoxide (400 mg.) in methanol (200 ml.) was refluxed for 45 min. The solution was neutralized with Bio-Rad AG50-X2 (H), filtered and the filtrate was concentrated to a syrup. Crystallization of the syrup from methanolethyl acetate provided 8.0 g. (70.5%) of product with M.P. 117-199°.

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated to a syrup
  3. customCrystallization of the syrup from methanolethyl acetate
  4. customprovided 8.0 g

Sources & evidence

ORD record
ord-e1992b1ca59844ac8c0f0c373bac7943
Source dataset
uspto-grants-1978_11
Patent number
USRE029835

Reaction notes

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