HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ribavirin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylate | HCID 10150551 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ribavirin | HCID 37542 | 90% |
Reaction Steps
A solution of 1-(2,3,5-tri-O-acetyl-β -D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (10.0 g., 26.0 mmole) in methanol (70 ml.) saturated at 0° with anhydrous ammonia was kept in a sealed pressure flask at 25° for 18 hrs. The product was crystallized from ethanol to give 1-(β -D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (5.70 g., 90.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE029835 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-df85ffb2cfb44b359c7b99493654d008 |
| Source note | uspto-grants-1978_11 |