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HRID1703732

反应详情

EQUATION

反应方程式

HRID 1703732 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O
HCID83064

1,2,3,5-Tetraacetyl-.-d-ribofuranose

C13H18O9

结构：O=[N+]([O-])c1ccc(OP(=O)([O-])Oc2ccc([N+](=O)[O-])cc2)cc1
HCID5255575

未命名化合物

结构：N#Cc1nc[nH]n1
HCID178510603

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)OC[C@H]1O[C@@H](n2cnc(C#N)n2)[C@H](OC(C)=O)[C@@H]1OC(C)=O
HCID13456801

1-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carbonitrile

C14H16N4O7

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

A mixture of 3-cyano-1,2,4-triazole (9.41 g., 0.10 mol) and 1,2,3,5-tetra-O-acetyl-β -D-ribofuranose (31.8 g., 0.10 mol) was heated in an oil bath maintained at 150°. Bis(p-nitrophenyl) phosphate (100 mg.) was added with stirring and heating at 150° under diminished pressure was continued for 15 min. The residue was dissolved in chloroform, the solution was filtered and the solvent was removed. Crystallization of the residue from ether provided 28.2 g. (80%) of product with M.P. 96-97°.

WORKUP

后处理

  1. temperaturewas heated in an oil bath
  2. temperaturemaintained at 150°
  3. temperatureheating at 150° under diminished pressure
  4. filtrationthe solution was filtered
  5. customthe solvent was removed
  6. customCrystallization of the residue from ether
  7. customprovided 28.2 g