2-Amino-2-methyl-1,3-propanediol → (3-Methyl-1-oxa-4-azaspiro[4.5]decan-3-yl)methanol

Participants

Reaction Steps

The procedure of Example 1 was employed utilizing 2-amino-2-methyl-1,3-propanediol (42.05 grams; 0.4 mole) and cyclohexanone (39.26 grams; 0.4 mole) in 250 mls of toluene. After removing the toluene, the residue was distilled to obtain 37.7 grams (50.8% of theoretical; b.p. 120° C. at 2.0 mm.) of the desired compound.

Provenance & Evidence