HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-(Hydroxymethyl)cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Cyclohexanone | HCID 7967 | — |
| Product | 2-(Hydroxymethyl)cyclohexanone | HCID 21406 | — |
Reaction Steps
By condensing cyclohexanone (2) with formaldehyde, the 2-hydroxymethylcyclohexanone (3) is obtained, wherefrom, by reaction with phenylmagnesium bromide, 1-phenyl-cis-2-hydroxymethyl-r-1-cyclohexanol (4) is prepared, the latter being subsequently oxidized with potassium permanganate into the acid (1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04125558 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-388057d0e1d24e30a40315e868fc397a |
| Source note | uspto-grants-1978_11 |