反应详情

To a stirred suspension of 222 gms of 1-(4'-chloro[1,1']-biphenyl-4-yl)ethanone in 1500 ml of methanol add in a portionwise fashion, 21 gms of sodium borohydride. Reflux and stir the mixture on a steam bath for 2 hours and stir at room temperature overnight. Concentrate the mixture to 500 ml, dilute with water, cool and filter the product to yield 238 gms of 1-(4'-chloro[1,1']biphenyl-4-yl)ethanol.

1. temperatureReflux
2. stirringstir at room temperature overnight
3. concentrationConcentrate the mixture to 500 ml
4. additiondilute with water
5. temperaturecool
6. filtrationfilter the product