反应详情

With constant stirring, reflux a solution of 25.1g of 4'-chloro-4-(1-chloroethyl)[1,1']biphenyl, 51g of 1-acetyl piperazine and 400 ml of anhydrous benzene for 24 hours. Add 200 ml of water to the reaction mixture, separate the organic phase, water-wash (5 times with 200 mls of water). Dry (over sodium sulfate), concentrate (in vacuo) and recrystallize the resulting residue from ethyl acetate to obtain the desired product.

1. customseparate the organic phase, water-
2. washwash (5 times with 200 mls of water)
3. dry with materialDry (over sodium sulfate)
4. concentrationconcentrate (in vacuo)
5. customrecrystallize the resulting residue from ethyl acetate