Benzene → HCID 22760339, compound

HRID 1703789Notes

Reaction equation

HRID 1703789 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14](Cl)[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(=[O:19])[CH3:18].C1C=CC=CC=1>O>[C:17]([N:20]1[CH2:25][CH2:24][N:23]([CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[CH:9][CH:10]=2)[CH3:15])[CH2:22][CH2:21]1)(=[O:19])[CH3:18]

Participants

5

Reactant 3

HCID 241BenzeneHCID 837951-AcetylpiperazineHCID 14674270HCID 14674270, compound

Product 1

HCID 22760339HCID 22760339, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

With constant stirring, reflux a solution of 25.1g of 4'-chloro-4-(1-chloroethyl)[1,1']biphenyl, 51g of 1-acetyl piperazine and 400 ml of anhydrous benzene for 24 hours. Add 200 ml of water to the reaction mixture, separate the organic phase, water-wash (5 times with 200 mls of water). Dry (over sodium sulfate), concentrate (in vacuo) and recrystallize the resulting residue from ethyl acetate to obtain the desired product.

Workup

  1. customseparate the organic phase, water-
  2. washwash (5 times with 200 mls of water)
  3. dry with materialDry (over sodium sulfate)
  4. concentrationconcentrate (in vacuo)
  5. customrecrystallize the resulting residue from ethyl acetate

Sources & evidence

ORD record
ord-77ab78ac608043ce93bb9e26d40dd695
Source dataset
uspto-grants-1978_11
Patent number
US04125612

Reaction notes

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