HCID 22760702, compound → HCID 22760700, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 32.0 g of 2-[4-(p-acetamidobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid in a mixture of 580 ml of 13% hydrochloric acid and 140 ml of 50% acetic acid was heated at 90° C. for 70 minutes with stirring and concentrated to dryness under reduced pressure. The residue was dissolved in 200 ml of water, the solution made alkaline with 20 ml of a 50% sodium hydroxide solution, and adjusted to pH 7.5 with acetic acid. The crystalline precipitate was collected and recrystallized from ethanol to give the product (22.6 g), m.p. 198°-201° C.

Provenance & Evidence