Pipemidic Acid → HCID 22760701, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.0 g of 2-(1-piperazinyl)-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid, 1.34 g of triethylamine, 2.14 g of p-nitrobenzyl bromide, and 50 ml of dimethylformamide was heated at 90° C. for 14 hours with stirring and concentrated to dryness under reduced pressure. Addition of 50 ml of water to the residue resulted in the separation of a solid, which was collected and recrystallized from dimethylformamide to give the product (2.02 g), m.p. 259°-261° C.

Provenance & Evidence