HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → Benzo(b)thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Reactant | n-Butyl lithium | HCID 61028 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
Reaction Steps
Thionaphthene was treated in a carboxylation reaction in accordance with the procedure described by D. A. Shirley and M. D. Cameron, in J. Am. Chem. Soc., 72, 2788, 1950 using N-butyllithium in ether, followed by carbonation with dry ice, and hydrolysis to the acid. The product had a melting point of 238°-239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04125621 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-b66f986d68c14e8cb544eda9eaa4fec6 |
| Source note | uspto-grants-1978_11 |