N,N,N',N'-Tetramethylethylenediamine → HCID 22759855, compound

Participants

Reaction Steps

Following the procedure which is described in Example 4, 2.91 parts of 2-(2,2-diphenylethyl)-1-azabicyclo[2.2.2]octane in 40 parts by volume of cyclohexane, 5.1 parts by volume of a 2.17 M solution of butyl lithium in hexane are reacted with 1.5 parts of TMEDA and 1.81 parts of n-hexyl bromide to provide 2-(2,2-diphenyloctyl)-1-azabicyclo[2.2.2]octane. This compound is then treated with 0.730 parts of maleic acid to give 2-(2,2-diphenyloctyl)-1-azabicyclo[2.2.2]octane maleate, melting at about 180°-181° C. This compound is represented by the following structural formula ##STR10##

Provenance & Evidence