N,N,N',N'-Tetramethylethylenediamine → HCID 22759863, compound

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Reaction Steps

Following the procedure which is described in Example 4, 2.91 parts of 2-(2,2-diphenylethyl)-1-azabicyclo[2.2.2]octane in 40 parts by volume of cyclohexane, 5.1 parts by volume of a 2.17 M solution of butyl lithium in hexane are reacted with 1.5 parts by volume of TMEDA and 1.65 parts of 1-bromopentane to provide 2-(2,2-diphenylheptyl)-1-azabicyclo[2.2.2]octane. This compound is then treated with 0.570 parts of maleic acid to give 2-(2,2-diphenylheptyl)-1-azabicyclo[2.2.2]octane maleate, melting at about 177°-178.5° C. This compound is represented by the following structural formula ##STR11##

Provenance & Evidence