N,N'-Dimethylthiourea → HCID 22760480, compound

HRID 1703843Notes

Reaction equation

HRID 1703843 reaction equation
[Br:1][CH:2]([CH2:16][CH3:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH3:18][NH:19][C:20]([NH:22][CH3:23])=[S:21]>CO>[BrH:1].[CH2:16]([CH:2]1[S:21][C:20](=[N:19][CH3:18])[N:22]([CH3:23])[C:3]1([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)[OH:4])[CH3:17]

Participants

4

Reactant 2

HCID 2723631N,N'-DimethylthioureaHCID 22756444HCID 22756444, compound

Product 1

HCID 22760480HCID 22760480, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.6 g of 2-bromo-4'-chloro-3'-sulfamoyl-butyrophenone and 1.7 g of 1,3-dimethylthio urea were heated in 50 ml of methanol for 10 minutes to 40° C. and stirred for another 2 hours at room temperature. Precipitation followed by adding diisopropyl ether and the oily end product was crystallized with diethyl ether. Colorless solid body: decomposition from 98° C. on, γC=N 1620 cm-1.

Workup

  1. customPrecipitation
  2. additionby adding diisopropyl ether
  3. customthe oily end product was crystallized with diethyl ether
  4. customfrom 98° C.

Sources & evidence

ORD record
ord-8148db0b979b46aea517962dced89827
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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