N,N'-Dibutylthiourea → 3-n-Butyl-2-n-butylimino-4-(4-chloro-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide

HRID 1703848Notes

Reaction equation

HRID 1703848 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH3:27])=[S:22])[CH2:17][CH2:18][CH3:19]>>[BrH:1].[CH2:24]([N:23]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:22][C:21]1=[N:20][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 2723622N,N'-DibutylthioureaHCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenone

Product 1

HCID 227606863-n-Butyl-2-n-butylimino-4-(4-chloro-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide

Procedure

6.2 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone were reacted with 3.8 g of 1,3-di-n-butylthiourea according to the prescription given in Example 12 and the end product was precipitated with diisopropyl ether. Colorless amorphous solid body: decomposition beginning at 100° C., γC=N 1615 cm-1.

Workup

  1. customthe end product was precipitated with diisopropyl ether
  2. custombeginning at 100° C.

Sources & evidence

ORD record
ord-537e8ae6f76342a3b1b0dced6e0de0fd
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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