1-cyclohexyl-3-(pyridin-3-ylmethyl)thiourea → HCID 22760631, compound

HRID 1703877Notes

Reaction equation

HRID 1703877 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:22][C:23]([NH:25][CH2:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[BrH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:24][C:23](=[N:25][CH2:26][C:27]3[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=3)[N:22]2[CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 45848961-cyclohexyl-3-(pyridin-3-ylmethyl)thioureaHCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenone

Product 1

HCID 22760631HCID 22760631, compound

Procedure

4.7 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone and 3.7 g of 1-cyclohexyl-3-(3-pyridylmethyl)-thiourea were reacted as prescribed in Example 23. The end product precipitated first as oil and crystallized after stirring for several hours at room temperature. Colorless crystals, melting point 140° C., decomposition beginning at 165° C., γC=N 1600 cm-1.

Workup

  1. customThe end product precipitated first as oil
  2. customcrystallized
  3. customat 165° C.

Sources & evidence

ORD record
ord-0cbd1f36dcb34e72b872986fa366faa6
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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