HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1703901Generated: October 30, 2026
Tert-Butylamine → 3-(tert-butylsulfamoyl)-4-chlorobenzoic acid
https://huagongshe.com/reaction/1703901
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 4-Chloro-3-(chlorosulphonyl)benzoic acid | HCID 75613 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(tert-butylsulfamoyl)-4-chlorobenzoic acid | HCID 2393878 | — |
Reaction Steps
To a mixture of 36.5 g (0.5 mol) of tert.-butylamine and 250 ml of ethanol were added 25.5 g (0.1 mol) of 4-chloro-3-chlorosulfonylbenzoic acid in small portions while stirring and cooling, the reaction temperature being maintained at about 30° C. After a dwelling time over night at room temperature, the solvent was distilled off, the residue was dissolved in about 200 ml of water, the pH was adjusted to 1 with concentrated HCl and the crystals were filtered off. Melting point: 250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04125614 |
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| Source dataset | uspto-grants-1978_11 |
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| ORD ID | ord-780e37b9381c41d286a8c680ef7a74f8 |
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| Source note | uspto-grants-1978_11 |
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