HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Acetyl-2-fluorobenzenesulphonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3'-Amino-4'-fluoroacetophenone | HCID 10606953 | — |
| Reactant | 3'-Chlorosulfonyl-4'-fluoroacetophenone | HCID 22760444 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Acetyl-2-fluorobenzenesulphonamide | HCID 21331652 | — |
Reaction Steps
4.9 g of 3'-amino-4'-fluoroacetophenone were diazotized in 25 ml of concentrated hydrochloric acid at 0° to 5° C. with a solution of 2.3 g of NaNO2 in 5 ml of water and treated with a solution, prepared from 2.7 g of sodium bisulfite in 5 ml of water and 25 ml of concentrated hydrochloric acid and the oily 3'-chlorosulfonyl-4'-fluoroacetophenone was reacted with 20 ml of liquid ammonia to give the 4'-fluoro-3'-sulfamoylacetophenone, melting point: 135° C. from glacial acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04125614 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-bb692793f0fb4d439bf9fd1cd76775a0 |
| Source note | uspto-grants-1978_11 |