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p-Toluenesulfonic acid → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Barium Oxide Nanoparticle Dispersion | HCID 9855530 | — |
| 反応物 | Tetramethylbenzyl ammonium hydroxide | HCID 19860286 | — |
| 生成物 | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
反応手順
The above procedure is repeated in all respects, excepting that the strong base reagent is altered, In separate experiments, sodium hydride, potassium hydroxide, barium oxide, diisopropylethylamine, 1,5-diazobicylo[5.4.0]undicene5, tetramethylguanidine, tetramethylbenzyl ammonium hydroxide, Amberlite A21 (Rohm & Haas) strongly basic ion exchange resin or p-toluene sulfonic acid, are substituted for sodium hydroxide and yield the desired 3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione. In practice of the above-described method, sodium hydroxide or sodium hydride in refluxing toluene is preferred.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04125727 |
| 出典データセット | uspto-grants-1978_11 |
| ORD ID | ord-c14705e1a1124e52b08757da855bc58d |
| 出典メモ | uspto-grants-1978_11 |