HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | alpha-Isopropyl-alpha-methyl-1,3-dioxo-2-isoindolineacetamide | HCID 4916589 | — |
| Product | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
Reaction Steps
Following the procedure described in Example 1 and sodium hydride as the base, but substituting (-)-α-isopropyl-α-methyl-1,3-dioxo-2-isoindolineacetamide for the racemic compound, the product (+)-3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione is obtained, melting point 137.5-139° C, [α]D25 +64.54 (THF, C 0.097).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04125727 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-3bfe356c2a6945ffa6e2ec74554bba2e |
| Source note | uspto-grants-1978_11 |