Water → N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

HRID 1704009Notes

Reaction equation

HRID 1704009 reaction equation
S1CCS[C:2]21[C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]2.O.C(=O)([O-])[O-:19].[Ca+2]>C(#N)C>[O:19]=[C:2]1[C:10]2[S:11][CH:12]=[CH:13][C:9]=2[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 10112Calcium CarbonateHCID 86735494N-(5,6-dihydrospiro[benzo-[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide

Product 1

HCID 23347790N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a stirred mixture of N-(5,6-dihydrospiro[benzo[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide (1.5 g), acetonitrile (20 ml) and water is added calcium carbonate (1.65 g) and mercuric chloride (3.0 g). The mixture is stirred at room temperature for 35 minutes and acetonitrile is added. The solid is filtered and washed with acetonitrile. The filtrate (100 ml) is evaporated to dryness to afford the title compound.

Workup

  1. filtrationThe solid is filtered
  2. washwashed with acetonitrile
  3. customThe filtrate (100 ml) is evaporated to dryness

Sources & evidence

ORD record
ord-5d904847e63740b9b37dd607a96e547d
Source dataset
uspto-grants-1978_11
Patent number
US04125539

Reaction notes

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