4-Fluorophenol → HCID 20392581, compound

Participants

Reaction Steps

To a solution of 1.87 g of p-fluorophenol in 50 ml of methanol is added 1.07 g of sodium methoxide. To this solution is added 5.4 g of methyl α-bromo-α-[p-(p-chlorophenoxy)phenyl]acetate and the mixture is refluxed for 18 hours. The mixture is concentrated to 1/2 volume and poured into 150 ml of ice and water. The mixture is extracted with ether and the cold extracts washed with 50 ml of 2N NaOH and with saline. After drying (MgSO4), the extracts are concentrated under vacuum to give the product as an amber colored oil.

Provenance & Evidence