反应详情

To a solution of 4.62 g of 2-chloro-4-tert-butylphenol, 1.188 g of sodium methoxide and 50 mg of potassium iodide in 40 ml of methanol is added 7.11 g of methyl α-bromo-α-[p-(p-chlorophenoxy)phenyl]acetate in 10 ml of benzene. The mixture is heated at reflux overnight. The mixture is worked up as described in Example 68 to yield a yellow oil. Chromatography on 100 g of silica gel (benzene, 400 ml) affords an oil which solidifies. Recrystallization from hexane yields white plates, mp 85.5°-88° C.

1. temperatureThe mixture is heated
2. temperatureat reflux overnight
3. customto yield a yellow oil
4. customChromatography on 100 g of silica gel (benzene, 400 ml) affords an oil which
5. customRecrystallization from hexane
6. customyields white plates, mp 85.5°-88° C.