Potassium Iodide → HCID 12531868, compound

Participants

Reaction Steps

To a solution of 4.08 g of α,α,α-trifluoro-p-cresol, 1.19 g of sodium methoxide and 50 mg of potassium iodide in 40 ml of methanol is added 7.11 g of methyl α-bromo-α-[p-(p-chlorophenoxy)phenyl]acetate in 10 ml of benzene. The mixture is refluxed overnight and then poured into 100 ml of water. The mixture is then extracted with 2 × 75 ml of ether. The combined extracts are washed with 2 × 50 ml of 5% NaOH, 50 ml of water, 50 ml of saturated brine and dried (MgSO4). Evaporation of the solvent yields a yellow oil. Chromatography on 100 g of silica gel (benzene, 400 ml) affords the product as a colorles oil.

Provenance & Evidence