4-Fluorophenol → HCID 12531880, compound

Participants

Reaction Steps

To a solution of 2.7 g of p-fluorophenol in 20 ml of methanol was added 1.89 g of sodium methoxide. To the solution was added 7.98 g of methyl α-bromo-α-[p-(p-methylsulfonylphenoxy)phenyl]acetate in 40 ml of methanol. The mixture was refluxed and stirred for 18 hours, chilled and filtered to give 4.3 g of white crystals, mp 135°-137° C. Recrystallization from acetone-hexane gave the product as white crystals, mp 136°-138° C.

Provenance & Evidence